Major Employers
| Name | Type | Employees |
|---|---|---|
| Mosaic Life Care | Health Care | 2922 |
| Triumph Foods, LLC | Meat products | 2781 |
| 139th Airlift Wing | Missouri Air Guard | 1663 |
| St. Joseph School District | Education | 1635 |
| Boehringer Ingelheim Animal Health | Animal Parmaceuticals | 946 |
| Clarios, Inc. (former: Johnson Controls, Inc.-Battery Division) | Manufacturing/Distribution | 727 |
| Tyson Foods | Meat products | 670 |
| City of St. Joseph | Municipal Services | 649 |
| American Family Insurance | Insurance | 631 |
| Missouri Western State University | Education | 579 |
| Missouri Department of Transportation | Transportation | 490 |
| Alorica | Financial services | 481 |
| Daily's Premium Meats | Meat products | 390 |
| Nestle Purina PetCare | Manufacturing | 272 |
| Blue Scope Buildings North American | Manufacturing | 251 |
| National Beef Leathers | Manufacturing | 200 |
| Hillyard Companies | Manufacturing | 198 |
| Sealed Air Corporation | Manufacturing | 195 |
| Gray Manufacturing | Manufacturing | 181 |
| International papers | Manufacturing | 172 |
| Lifeline Foods | Manufacturing | 160 |
| Nestle Product and Technology Center | Product Development | 150 |