Major Employers
| Name | Type | Employees |
|---|---|---|
| University of Missouri | Higher Education | 8480 |
| University Hospital and Clinics | Health services | 5304 |
| Columbia Public Schools | Education | 2672 |
| Veterans United Home Loans | Mortgage lender | 2360 |
| Harry S. Truman Memorial Veterans' Hospital | Health services | 1602 |
| City of Columbia | Government | 1371 |
| Boone Hospital Center | Health services | 1357 |
| Shelter Insurance Companies | Insurance | 1277 |
| Joe Machens Dealerships | Automobile dealership | 778 |
| MBS Textbook Exchange | Textbook operation | 730 |
| Columbia College | Higher Education | 580 |
| IBM | Information Technology | 503 |
| State of Missouri (Excludes MU) | Government | 503 |
| State Farm Insurance Companies | Insurance | 500 |
| Boone County Government | Government | 475 |
| 3M | Manufacturing | 464 |
| Kraft Heinz | Manufacturing | 450 |
| Central Bank of Boone County | Financial services | 325 |
| Missouri Employers Mutual | Insurance | 311 |
| MidwayUSA | Outdoor retailer | 300 |
| Landmark Bank/Simmons Bank | Financial services | 276 |
| Quaker Oats Company | Manufacturing | 265 |
| Eurofins BioPharma Product Testing Columbia, Inc. | BioScience | 255 |
| MFA, Inc. | Agricultural cooperative | 241 |
| Dana Light Axle Products | Manufacturing | 231 |
| Woodhaven | Care for developmentally disabled | 231 |
| AAF Flanders | Air filter supplier | 216 |
| Schneider Electric: Square D | Manufacturing | 214 |
| Burrel Behavioral Health | Mental health services | 188 |
| U.S. Dept. of Agriculutre | Government | 185 |
| CenturyLink | Internet provider | 180 |
| American Outdoor Brands | Manufacturing | 174 |
| Columbia Insurance Group | Insurance | 163 |
| U.S. Postal Service | Government | 150 |
| Columbia Orthopaedic Group | Health services | 130 |
| EquipmentShare | Construction equipment rental | 130 |
| OTSCON | Manufacturing | 118 |
| Aurora Organic Dairy | Milk plant | 117 |
| Environmental Dynamics International, Inc. (EDI) | Manufacturing | 105 |
| Miller's Professional Imaging | Printing laboratory | 100 |